Generic placeholder image

Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

X-Ray Structure of HIV-1 Protease Tethered Dimer Complexed to Ritonavir

Author(s): Amit Das, Dharmaraj Ramachandra Rao and Madhusoodan Vijayacharya Hosur

Volume 14, Issue 6, 2007

Page: [565 - 568] Pages: 4

DOI: 10.2174/092986607780989930

Price: $65


We report here the 2.5Å structure of HIV-1 protease tethered-dimer ritonavir complex. The inhibitor bound in the active site has different conformations in the two orientations. There is only one hydrogen bond between the inhibitor and the enzyme. The conserved flap-water is not found in the present complex.

Keywords: HIV-1 protease, tethered dimmer, inhibitor, X-ray crystallography

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy