Abstract
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures.
Keywords: Privileged structures, pharmacophoric point, rational drug design, bioactive N-acylhydrazones derivatives
Mini-Reviews in Medicinal Chemistry
Title: Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates
Volume: 7 Issue: 11
Author(s): Carolina D. Duarte, Eliezer J. Barreiro and Carlos A.M. Fraga
Affiliation:
Keywords: Privileged structures, pharmacophoric point, rational drug design, bioactive N-acylhydrazones derivatives
Abstract: Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures.
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Cite this article as:
Duarte D. Carolina, Barreiro J. Eliezer and Fraga A.M. Carlos, Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates, Mini-Reviews in Medicinal Chemistry 2007; 7 (11) . https://dx.doi.org/10.2174/138955707782331722
DOI https://dx.doi.org/10.2174/138955707782331722 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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