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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Application of Olefin Cross-Metathesis to the Synthesis of Biologically Active Natural Products

Author(s): Joelle Prunet

Volume 5, Issue 15, 2005

Page: [1559 - 1577] Pages: 19

DOI: 10.2174/156802605775009801

Price: $65


An overview of the use of olefin cross-metathesis in the synthesis of biologically active natural products is presented. The diverse examples are organized according to the outcome of the olefin constructed by the cross-metathesis reaction: this olefin can be either present in the final product, reduced, engaged in other transformations, or involved in tandem processes.

Keywords: furaquinocin B, platelet aggregation, reductive cyclization, Deprotection, homodimerization, Amphidinium sp, pyridinium para-toluenesulfonate (PPTS)

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