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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Annulation of a 4-pyrrolylbutanal to a 5,6-dihydroindolizine Core: A Novel Diastereoselective Synthesis of (±)-Indolizidine 167B

Author(s): Roberta Settambolo, Giuditta Guazzelli and Raffaello Lazzaroni

Volume 2, Issue 2, 2005

Page: [176 - 178] Pages: 3

DOI: 10.2174/1570178053202847

Price: $65


The synthesis of (±)-Indolizidine167B has been accomplished in 4 steps and 13.5 % overall yield from 4-carboxyethyl-4-(pyrrol-1-yl)butanal (1) via successive manipulations of 5,6-dihydroindolizine intermediates and final diastereoselective hydrogenation .

Keywords: 4-pyrrolylbutanal, intramolecular cyclodehydration, indolizidine 167b, 5,6-dihydroindolizines

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