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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

A Cellular ELISA to Screen Lectin-Like Compounds for Cancer Cell Binding

Author(s): C- P. Chang, W- C. Cheng and H- Y. Lei

Volume 2, Issue 3, 2005

Page: [182 - 188] Pages: 7

DOI: 10.2174/1570180053765228

Price: $65


Lectins are carbohydrate-binding proteins that can modulate cellular activity through cell membrane glycoproteins. A cell-based binding was set up to screen the lectin-like substances in natural products. Lectins, after binding to tumor cells, are detected with a biotinylated carbohydrate-polyacrylamide complex by ELISA. Sugar specificity can also be determined within the assay.

Keywords: lectin, elisa, apoptosis, mitogenic

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