A Cellular ELISA to Screen Lectin-Like Compounds for Cancer Cell Binding

Title: A Cellular ELISA to Screen Lectin-Like Compounds for Cancer Cell Binding

Volume: 2 Issue: 3

Author(s): C- P. Chang, W- C. Cheng and H- Y. Lei

Affiliation:

Keywords: lectin, elisa, apoptosis, mitogenic

Abstract: Lectins are carbohydrate-binding proteins that can modulate cellular activity through cell membrane glycoproteins. A cell-based binding was set up to screen the lectin-like substances in natural products. Lectins, after binding to tumor cells, are detected with a biotinylated carbohydrate-polyacrylamide complex by ELISA. Sugar specificity can also be determined within the assay.

Cite this article as:

Chang P. C-, Cheng C. W- and Lei Y. H-, A Cellular ELISA to Screen Lectin-Like Compounds for Cancer Cell Binding, Letters in Drug Design & Discovery 2005; 2 (3) . https://dx.doi.org/10.2174/1570180053765228