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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

The Rationale and Development of New Drugs to Treat HIV Infection

Author(s): J. Stebbing, E. Hatzimichael, M. Bower and A. Winston

Volume 1, Issue 6, 2005

Page: [635 - 642] Pages: 8

DOI: 10.2174/157340605774598199

Price: $65


Fewer than one million HIV infected individuals are currently receiving antiretroviral therapy. Present antiretroviral therapy costs between $10,000 and $20,000 per year, which provides excellent value for money in developed countries with a cost of about $10,000 per life year saved; this compares very favourably with other therapies in chronic use. Recent studies have demonstrated a dramatic decline in HIV and AIDS related morbidity and mortality across developed countries and these reductions have been sustained since the introduction of highly active antiretroviral therapy (HAART) since 1996. The use of HAART has been associated with specific toxicities related to the drug class, problems with adherence with the subsequent emergence of viral isolates and resistance associated mutations. The replacement of older therapies with newer drugs that avoid cross resistance even within the same class of antiretroviral, represents a new hope in retroviral targeting.

Keywords: antiretroviral therapy, proteinase inhibitors, Reverse transcriptase inhibitors, Elvucitabine, Amdoxovir, thymidine-associated mutations, Capravirine

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