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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Development of Radioligands for In Vivo Imaging of GABAA-Benzodiazepine Receptors

Author(s): Andrew Katsifis and Michael Kassiou

Volume 4, Issue 8, 2004

Page: [909 - 921] Pages: 13

DOI: 10.2174/1389557043403332

Price: $65


Changes in the biochemical integrity and function of the GABAA-benzodiazepine receptor (BZR) complex have been implicated in various neurological and psychiatric disorders. The development of specific radioligands for the GABAA-BZR have not only contributed to the elucidation of the receptors biochemical functions, but also provided a means by which these changes are correlated to disease states when studied with the functional imaging modalities of positron emission tomography (PET) and single photon emission computed tomography (SPECT).

Keywords: benzodiazepines, cns receptors, radioligands, pet, spect

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