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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Human Insulin Genome Sequence Map, Biochemical Structure of Insulin for Recombinant DNA Insulin

Author(s): Chiranjib Chakraborty and Ashish A. Mungantiwar

Volume 3, Issue 5, 2003

Page: [375 - 385] Pages: 11

DOI: 10.2174/1389557033488024

Price: $65


Insulin is a essential molecule for type I diabetes that is marketed by very few companies. It is the first molecule, which was made by recombinant technology; but the commercialization process is very difficult. Knowledge about biochemical structure of insulin and human insulin genome sequence map is pivotal to large scale manufacturing of recombinant DNA Insulin. This paper reviews human insulin genome sequence map, the amino acid sequence of porcine insulin, crystal structure of porcine insulin, insulin monomer, aggregation surfaces of insulin, conformational variation in the insulin monomer, insulin X-ray structures for recombinant DNA technology in the synthesis of human insulin in Escherichia coli.

Keywords: Human Insulin, DNA technology, Genome Sequence Map

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