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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Application of Pharmacophore Models for the Design and Synthesis of New Anticonvulsant Drugs

Author(s): Barbara Malawska

Volume 3, Issue 4, 2003

Page: [341 - 348] Pages: 8

DOI: 10.2174/1389557033488088

Price: $65

Abstract

The chemical diversity and various mechanisms of action of anticonvulsants make it difficult to identify a common pharmacophore. The present review outlines different pharmacophore models for anticonvulsant activity with emphasis on the development of new drugs. Some of them represent models for structurally different classes of compounds with similar mechanisms of action. Others represent pharmacophore models for similar chemical classes of compounds for which the mechanism of anticonvulsant action is not clear. A pharmacophore model for sodium channel blocking compounds, anticonvulsants with the phthalimide pharmacophore, a model for anticonvulsant semicarbazones, and a model for GABA uptake inhibitors are presented.

Keywords: pharmacophore models, anticonvulsants, na-channel blockers, 4-aminobenzamide, n-phenylphthalimide, semicarbazones, gaba uptake inhibitors


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