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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Solid-Phase Synthesis of Structurally Diverse Scaffolded Peptides for the Mimicry of Discontinuous Protein Binding Sites

Author(s): Raimo Franke, Christian Doll, Victor Wray and Jutta Eichler

Volume 10, Issue 6, 2003

Page: [531 - 539] Pages: 9

DOI: 10.2174/0929866033478519

Price: $65


Scaffolded peptides, in which fragments of the sequence are presented through a molecular scaffold in a discontinuous and nonlinear fashion, are promising candidates for the mimicry of discontinuous protein binding sites. Twelve scaffold molecules based on cyclic peptides with ring sizes ranging from 13 to 30 were generated. Up to three different peptide fragments were attached to the scaffolds in a site-selective manner, yielding scaffolded peptides in excellent purities, as documented by MS, HPLC, and 2D 1H NMR spectroscopy data.

Keywords: solid-phase synthesis, scaffolded peptides, discontinuous protein, binding sites, molecular scaffold

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