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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Structural Investigation of Proapoptotic Peptide by Cd and Nmr Spectroscopy

Author(s): Emy Pulsinelli, Francesca Vasile, Laura Vergani, Silvio Parodi and Claudio Nicolini

Volume 10, Issue 6, 2003

Page: [541 - 549] Pages: 9

DOI: 10.2174/0929866033478528

Price: $65


We have performed a systematic investigation of the structural features of the peptides Int (a sequence able to cross cell membranes) and Int-H1(S6A,F8A) (which shows interesting antitumoral properties). After screening in aqueous solution at different ionic strength and pH values, we analyzed the structures of the peptides in different water / trifluoroethanol mixtures by Circular Dichroism and Nuclear Magnetic Resonance techniques.

Keywords: proapoptotic sequence, internalization sequence, circular dichroism, nmr spectroscopy, molecular dynamics, trifluoroethanol

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