Structural Investigation of Proapoptotic Peptide by Cd and Nmr Spectroscopy

Title: Structural Investigation of Proapoptotic Peptide by Cd and Nmr Spectroscopy

Volume: 10 Issue: 6

Author(s): Emy Pulsinelli, Francesca Vasile, Laura Vergani, Silvio Parodi and Claudio Nicolini

Affiliation:

Keywords: proapoptotic sequence, internalization sequence, circular dichroism, nmr spectroscopy, molecular dynamics, trifluoroethanol

Abstract: We have performed a systematic investigation of the structural features of the peptides Int (a sequence able to cross cell membranes) and Int-H1(S6A,F8A) (which shows interesting antitumoral properties). After screening in aqueous solution at different ionic strength and pH values, we analyzed the structures of the peptides in different water / trifluoroethanol mixtures by Circular Dichroism and Nuclear Magnetic Resonance techniques.

Cite this article as:

Pulsinelli Emy, Vasile Francesca, Vergani Laura, Parodi Silvio and Nicolini Claudio, Structural Investigation of Proapoptotic Peptide by Cd and Nmr Spectroscopy, Protein & Peptide Letters 2003; 10(6) . https://dx.doi.org/10.2174/0929866033478528