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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Nerve Membrane Ion Channels as the Target Site of Insecticides

Author(s): Toshio Narahashi

Volume 2, Issue 4, 2002

Page: [419 - 432] Pages: 14

DOI: 10.2174/1389557023405927

Price: $65


Most insecticides are potent neurotoxicants that act on various neuroreceptors and ion channels. However, the major target receptors are limited to sodium channels, GABA receptors, and nicotinic acetylcholine receptors. DDT and pyrethroids act similarly on sodium channels to keep them open leading to hyperexcitation. Indoxacarb inhibits sodium channels and certain subtypes of nicotinic receptors. Dieldrin, lindane and fipronil block GABA receptors. Imidacloprid modulates nicotinic receptors in a complex manner. Spinosads major target site appears to be nicotinic receptors.

Keywords: imidacloprid, insecticide, Ion channel, neurotoxicant, indoxacarb

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