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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Crystallization and Preliminary X-Ray Crystallographic Studies of Trichosanthin Delta C7

Author(s): X. Li, Y. Ding, H. Too, Z. Wang, Yi. Liu, Y. Dong, P. Shaw and Z. Rao

Volume 9, Issue 3, 2002

Page: [269 - 273] Pages: 5

DOI: 10.2174/0929866023408742

Price: $65

Abstract

Trichosanthin (TCS) is a type I ribosome-inactivating protein (RIP) which possesses rRNA N-glycosidase activity. TCS has various pharmacological properties. It is possible to reduce the antigenicity of TCS by deleting up to seven C-terminal residues of TCS (TCS-C7) with minimal effect on its activity [1]. TCS-C7 has been crystallized and the crystal diffracted to 1.8 Å. It belongs to space group P21, with unit-cell parameters a=71.6Å, b=74.4Å, c=87.6Å, β=97.0°. It is given that there are four molecules per asymmetric unit.

Keywords: trichosan thin deltac7, rip, ribosome-inactivating protein, trichosanthin(tcs), tcs-c7

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