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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery

Author(s): Robert H. Shoemaker, Dominic A. Scudiero, Giovanni Melillo, Michael J. Currens, Anne P. Monks, Alfred A. Rabow, David G. Covell and Edward A. Sausville

Volume 2, Issue 3, 2002

Page: [229 - 246] Pages: 18

DOI: 10.2174/1568026023394317

Price: $65


Increasing insight into the genetics and molecular biology of cancer has resulted in the identification of an increasing number of potential molecular targets for anti-cancer drug discovery and development. These targets can be approached through exploitation of emerging structural biology,”rational“ drug design, screening of chemical libraries, or a combination of these methods. In this article we discuss the application of high-throughput screening to anti-cancer drug discovery, with special reference to approaches used at the U.S. National Cancer Institute.

Keywords: anticancer drug discovery, molecular medicine, (cat) assays

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