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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Structural Studies of Herpesvirus Proteases

Author(s): Renu Batra, Reza Khayat and Liang Tong

Volume 8, Issue 5, 2001

Page: [333 - 342] Pages: 10

DOI: 10.2174/0929866013409229

Price: $65


Structural studies of herpesvirus proteases establish that they belong to a new class of serine proteases and contain a novel Ser-His-His catalytic triad. Peptidomimetic inhibitors bind to the protease by forming an anti-parallel beeta-sheet with the enzyme. There are large conformational changes in the protease upon inhibitor binding, indicating that the protease is an induced-fit enzyme. Further studies are needed to understand the molecular basis for the dimerization requirement of the protease.

Keywords: HERPESVIRUS PROTEASES, Serine proteases, Peptidomimetic inhibitors, Herpes simplex virus type 1 (HSV-1), HSV-2, varicellar-zoster virus (VZV), human cytomegalovirus (HCMV), human herpes virus 6 (HHV6), HHV7, gamma herpesviruses

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