Abstract
Some amyloid-derived peptides show their toxic effects only after a long “aging” period performed several days at pH 7.4 and 37 C for cluster formation. Our experiments show that long aging of beta-amyloid[25-35] under physiological conditions results in peptide bond cleavage between Asn27 and Lys28. Relatively short incubation time (24 hours) and absence of Ca2+ ions prevent peptide cleavage and results in good aggregation of beta-amyloids.
Keywords: AMYLOID PEPTIDE, Alzheimer disease
Protein & Peptide Letters
Title: In Vitro Degradation Of beta-Amyloid[25-35] Peptide
Volume: 8 Issue: 6
Author(s): Krisztina Jost, Jozsef Varga, Botond Pence and Marta Zarandi
Affiliation:
Keywords: AMYLOID PEPTIDE, Alzheimer disease
Abstract: Some amyloid-derived peptides show their toxic effects only after a long “aging” period performed several days at pH 7.4 and 37 C for cluster formation. Our experiments show that long aging of beta-amyloid[25-35] under physiological conditions results in peptide bond cleavage between Asn27 and Lys28. Relatively short incubation time (24 hours) and absence of Ca2+ ions prevent peptide cleavage and results in good aggregation of beta-amyloids.
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Cite this article as:
Jost Krisztina, Varga Jozsef, Pence Botond and Zarandi Marta, In Vitro Degradation Of beta-Amyloid[25-35] Peptide, Protein & Peptide Letters 2001; 8 (6) . https://dx.doi.org/10.2174/0929866013409076
DOI https://dx.doi.org/10.2174/0929866013409076 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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