Abstract
Peptidomimetic modifications are frequently used as attractive methods to provide more conformationally constrained and thus more stable and bioactive peptides. Among peptidomimetic approaches, particularly attractive are pseudopeptides, or peptide bond surrogates in which peptide bonds have been replaced with other chemical groups. Since these peptidomimetics can be constructed in a modular way from orthogonally protected monomeric building blocks, solid-phase Fmoc methodology, used routinely for peptide synthesis, emerged as a particularly attractive synthetic approach.
Keywords: Peptidomimetics, pseudopeptides, isosteres, Fmoc solid-phase synthesis
Mini-Reviews in Organic Chemistry
Title: Pseudopeptide Synthesis via Fmoc Solid-Phase Synthetic Methodology
Volume: 4 Issue: 4
Author(s): Predrag Cudic and Maciej Stawikowski
Affiliation:
Keywords: Peptidomimetics, pseudopeptides, isosteres, Fmoc solid-phase synthesis
Abstract: Peptidomimetic modifications are frequently used as attractive methods to provide more conformationally constrained and thus more stable and bioactive peptides. Among peptidomimetic approaches, particularly attractive are pseudopeptides, or peptide bond surrogates in which peptide bonds have been replaced with other chemical groups. Since these peptidomimetics can be constructed in a modular way from orthogonally protected monomeric building blocks, solid-phase Fmoc methodology, used routinely for peptide synthesis, emerged as a particularly attractive synthetic approach.
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Cite this article as:
Cudic Predrag and Stawikowski Maciej, Pseudopeptide Synthesis via Fmoc Solid-Phase Synthetic Methodology, Mini-Reviews in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157019307782411716
DOI https://dx.doi.org/10.2174/157019307782411716 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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