Abstract
In this short review we describe recent methods and novel trends for the introduction of fluorine-18 into molecules which in turn are intended to serve as imaging agents for the in vivo imaging modality positron emission tomography (PET). These 18F-labeling schemes are based on enzymatic fluorination, the use of ionic liquids, protic solvents acting as catalysts, application of “click chemistry”, thiol-reactive labeling agents for peptide and protein labeling and the most recent introduction of “non-classical” radiochemistry based on organo-phosphorous, organo-boron and organo-silicon radiochemistry. The latter approach for the first time introduced an 18F-chemistry characterized by high selectivity and unique efficiency making complicated work-up procedures obsolete.
Keywords: Fluorine-18, positron emission tomography (PET), labeling chemistry
Mini-Reviews in Organic Chemistry
Title: Recent Developments and Trends in 18F-Radiochemistry: Syntheses and Applications
Volume: 4 Issue: 4
Author(s): Ralf Schirrmacher, Carmen Wangler and Esther Schirrmacher
Affiliation:
Keywords: Fluorine-18, positron emission tomography (PET), labeling chemistry
Abstract: In this short review we describe recent methods and novel trends for the introduction of fluorine-18 into molecules which in turn are intended to serve as imaging agents for the in vivo imaging modality positron emission tomography (PET). These 18F-labeling schemes are based on enzymatic fluorination, the use of ionic liquids, protic solvents acting as catalysts, application of “click chemistry”, thiol-reactive labeling agents for peptide and protein labeling and the most recent introduction of “non-classical” radiochemistry based on organo-phosphorous, organo-boron and organo-silicon radiochemistry. The latter approach for the first time introduced an 18F-chemistry characterized by high selectivity and unique efficiency making complicated work-up procedures obsolete.
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Schirrmacher Ralf, Wangler Carmen and Schirrmacher Esther, Recent Developments and Trends in 18F-Radiochemistry: Syntheses and Applications, Mini-Reviews in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157019307782411699
DOI https://dx.doi.org/10.2174/157019307782411699 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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