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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Tetraspanins-Structural and Signalling Scaffolds that Regulate Platelet Function

Author(s): Matt W. Goschnick and Denise E. Jackson

Volume 7, Issue 12, 2007

Page: [1248 - 1254] Pages: 7

DOI: 10.2174/138955707782795656

Price: $65

Abstract

There are several tetraspanins present in platelets including CD9, CD151, TSSC6, and CD63. Recent studies in knockout mouse models have revealed that CD151 and TSSC6 are physically and functionally involved in regulation of the ‘outside-in’ signalling properties of the major platelet integrin, integrin αIIbβ3 and thrombus stability in vivo.

Keywords: Tetraspanin, integrin αIIbβ3, outside-in signalling, platelet thrombus formation


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