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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Concise Synthesis of Benzoindolizidine Derivatives and Bioactivity Evaluation

Author(s): Qingmin Wang, Mingbo Cui, Kailiang Wang and Runqiu Huang

Volume 5, Issue 2, 2008

Page: [98 - 102] Pages: 5

DOI: 10.2174/157017808783743867

Price: $65


Due to the profound cytotoxicities and interesting biochemical aspects, phenanthroindolizidine alkaloids have received attention as potential therapeutic leads. To define the features of the molecule that are essential for their excellent bioactivities, we have synthesized two hexahydropyrrolo[1,2-b]isoquinolines and their hydrochloride salts and picrates concisely and evaluated their antiviral and anticancer activities. We found that the replacement of the phenanthrene with a benzene in phenanthroindolizidine alkaloids observably decreased their antiviral and anticancer activities, and thus the phenanthrene in phenanthroindolizidine alkaloids is essential for high antiviral and anticancer activities.

Keywords: Benzoindolizidine, hydrochloride salt, picrate, synthesis, antiviral activity, anticancer activity

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