Circular Dichroism Reveals Sensitivity of Glucagon Solution Structure to Fluoroalcohols, pH and Ionic Strength

Title: Circular Dichroism Reveals Sensitivity of Glucagon Solution Structure to Fluoroalcohols, pH and Ionic Strength

Volume: 15 Issue: 8

Author(s): S. Guest, V. V. Ngo and M. A. Hefford

Affiliation:

Keywords: Glucagon, structure, fluoroalcohol, pH, ionic strength

Abstract: Circular dichroism reports that glucagon in solution becomes increasingly helical with the addition of fluoroalcohol (which also decreases solution pH), and with changes in pH and ionic strength. Given the variability of structure observed, these data indicate that care must be taken when comparing results obtained under different solution conditions.

Cite this article as:

Guest S., Ngo V. V. and Hefford A. M., Circular Dichroism Reveals Sensitivity of Glucagon Solution Structure to Fluoroalcohols, pH and Ionic Strength, Protein & Peptide Letters 2008; 15(8) . https://dx.doi.org/10.2174/092986608785203809