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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Circular Dichroism Reveals Sensitivity of Glucagon Solution Structure to Fluoroalcohols, pH and Ionic Strength

Author(s): S. Guest, V. V. Ngo and M. A. Hefford

Volume 15, Issue 8, 2008

Page: [811 - 817] Pages: 7

DOI: 10.2174/092986608785203809

Price: $65


Circular dichroism reports that glucagon in solution becomes increasingly helical with the addition of fluoroalcohol (which also decreases solution pH), and with changes in pH and ionic strength. Given the variability of structure observed, these data indicate that care must be taken when comparing results obtained under different solution conditions.

Keywords: Glucagon, structure, fluoroalcohol, pH, ionic strength

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