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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Apoptosis in Atherosclerosis: A Mini-Review

Author(s): Maria Karaflou, Irene Lambrinoudaki and George Christodoulakos

Volume 8, Issue 9, 2008

Page: [912 - 918] Pages: 7

DOI: 10.2174/138955708785132765

Price: $65


Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.

Keywords: Atherosclerosis, apoptosis, pathogenesis

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