Abstract
Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.
Keywords: Atherosclerosis, apoptosis, pathogenesis
Mini-Reviews in Medicinal Chemistry
Title: Apoptosis in Atherosclerosis: A Mini-Review
Volume: 8 Issue: 9
Author(s): Maria Karaflou, Irene Lambrinoudaki and George Christodoulakos
Affiliation:
Keywords: Atherosclerosis, apoptosis, pathogenesis
Abstract: Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.
Export Options
About this article
Cite this article as:
Karaflou Maria, Lambrinoudaki Irene and Christodoulakos George, Apoptosis in Atherosclerosis: A Mini-Review, Mini-Reviews in Medicinal Chemistry 2008; 8(9) . https://dx.doi.org/10.2174/138955708785132765
DOI https://dx.doi.org/10.2174/138955708785132765 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |

- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
Emerging Opportunities and Concerns for Drug Discovery at Serotonin 5-5-HT2B Receptors
Current Topics in Medicinal Chemistry Endogenous Cardiotonics: Search and Problems
Cardiovascular & Hematological Disorders-Drug Targets Role of the Akt Pathway in Prostate Cancer
Current Cancer Drug Targets Cathinone Neurotoxicity (“The “3Ms”)
Current Neuropharmacology Covid-19 in Man: A Very Dangerous Affair
Endocrine, Metabolic & Immune Disorders - Drug Targets History, Principle and Techniques for Waveform Optimization in External Defibrillations
Recent Patents on Engineering Potential Interactions between miRNAs and Hypoxia: A New Layer in Cancer Hypoxia
Anti-Cancer Agents in Medicinal Chemistry Subject Index To Volume 12
Current Pharmaceutical Design Aldosterone, From (Patho)Physiology to Treatment in Cardiovascular and Renal Damage
Current Vascular Pharmacology Antidepressants: Update on Benefits and Risks
Current Psychopharmacology Patent Selections
Recent Patents on Medical Imaging Efficient Expression and Purification of Recombinant Therapeutic Protein Candidates, Human Midkine and Pleiotrophin
Current Pharmaceutical Biotechnology Pharmacological Management of Type 2 Diabetes Mellitus: An Update
Current Diabetes Reviews Therapy for Dominant Inherited Diseases by Allele-Specific RNA Interference: Successes and Pitfalls
Current Gene Therapy Can Decision Making Research Provide a Better Understanding of Chemical and Behavioral Addictions?
Current Drug Abuse Reviews Current and Future Drugs for Appetite Regulation and Obesity Treatment
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Relationship of High-Sensitivity C-Reactive Protein Concentrations and Systolic Heart Failure
Current Vascular Pharmacology Statins Exert Multiple Beneficial Effects on Patients Undergoing Percutaneous Revascularization Procedures
Current Drug Targets Therapeutic Options and Emerging Alternatives for Multidrug Resistant Staphylococcal Infections
Current Pharmaceutical Design L-Arginine Modulates Glucose and Lipid Metabolism in Obesity and Diabetes
Current Protein & Peptide Science