Apoptosis in Atherosclerosis: A Mini-Review

Maria      Karaflou; Irene      Lambrinoudaki; George      Christodoulakos

Abstract

Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.

Keywords: Atherosclerosis, apoptosis, pathogenesis

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