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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Role and Pharmacogenomics of TNF-α in Asthma

Author(s): Dimosthenis Lykouras, Fotis Sampsonas, Alexandros Kaparianos, Kiriakos Karkoulias and Kostas Spiropoulos

Volume 8, Issue 9, 2008

Page: [934 - 942] Pages: 9

DOI: 10.2174/138955708785132828

Price: $65


Asthma is a chronic heterogeneous inflammatory disease of the respiratory system in which numerous cytokines play a significant role. Among them TNF-α (tumour necrosis factor α), a proinflammatory cytokine, has a predominant role in orchestrating airway inflammation and affecting treatment outcome. In this review we attempt to summarize the involvement of TNF-α in the pathogenesis of asthma, illustrate variations of TNF-α gene that potentially influence asthma phenotype and highlight promising therapies by blocking the production of TNF-α or inhibiting its action. A cytokine specific target therapy seems to be very promising since agents that block TNF-α slow disease progression, suppress inflammation and in some cases induce remission of chronic inflammation.

Keywords: Asthma, TNF, inflammatory disease, chronic inflammation., chronic heterpgeneous disease

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