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Inflammation & Allergy - Drug Targets (Discontinued)


ISSN (Print): 1871-5281
ISSN (Online): 2212-4055

The Role of Inflammation and Allergy in Acute Coronary Syndromes

Author(s): Beste Ozben and Okan Erdogan

Volume 7, Issue 3, 2008

Page: [136 - 144] Pages: 9

DOI: 10.2174/187152808785748128

Price: $65


It is well known that inflammatory mechanisms play a crucial role in the pathogenesis of atherosclerosis and coronary artery disease. In recent years, allergic episodes have been shown to be associated with acute coronary syndromes. Mast cells release certain inflammatory mediators including histamine and neutral proteases during an allergic episode and these inflammatory mediators are implied to induce coronary artery spasm and/or atheromatous plaque erosion or rupture. As the inflammatory component of acute coronary syndromes is a potential therapeutic target, drugs that stabilize mast cell membrane and monoclonal antibodies that protect mast cell surface may be effective in preventing allergy associated acute coronary syndromes. In this review, we will mention the role of inflammation and allergy and antiinflammatory therapeutic modalities in acute coronary syndromes.

Keywords: Acute coronary syndromes (ACS), Allergy, Inflammation, coronary artery disease, inflammatory mediators, pathogenesis, mast cell

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