Suramin: Clinical Uses and Structure-Activity Relationships

Title: Suramin: Clinical Uses and Structure-Activity Relationships

Volume: 8 Issue: 13

Author(s): Ross P. McGeary, Andrew J. Bennett, Quoc B. Tran, Kelly L. Cosgrove and Benjamin P. Ross

Affiliation:

Keywords: Suramin, trypanosomiasis, onchocerciasis, FGF

Abstract: Suramin is a polysulfonated polyaromatic symmetrical urea. It is currently used to treat African river blindness and African sleeping sickness. Suramin has also been extensively trialed recently to treat a number of other diseases, including many cancers. Here, we examine its modes of action and discuss its structure-activity relationships.

Cite this article as:

McGeary P. Ross, Bennett J. Andrew, Tran B. Quoc, Cosgrove L. Kelly and Ross P. Benjamin, Suramin: Clinical Uses and Structure-Activity Relationships, Mini-Reviews in Medicinal Chemistry 2008; 8(13) . https://dx.doi.org/10.2174/138955708786369573