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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Suramin: Clinical Uses and Structure-Activity Relationships

Author(s): Ross P. McGeary, Andrew J. Bennett, Quoc B. Tran, Kelly L. Cosgrove and Benjamin P. Ross

Volume 8, Issue 13, 2008

Page: [1384 - 1394] Pages: 11

DOI: 10.2174/138955708786369573

Price: $65


Suramin is a polysulfonated polyaromatic symmetrical urea. It is currently used to treat African river blindness and African sleeping sickness. Suramin has also been extensively trialed recently to treat a number of other diseases, including many cancers. Here, we examine its modes of action and discuss its structure-activity relationships.

Keywords: Suramin, trypanosomiasis, onchocerciasis, FGF

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