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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Apoptotic Signaling Pathways as a Target for the Treatment of Liver Diseases

Author(s): J. L. Mauriz, M. J. Tunon and J. Gonzalez-Gallego

Volume 8, Issue 14, 2008

Page: [1485 - 1493] Pages: 9

DOI: 10.2174/138955708786786499

Price: $65


Dysregulation of apoptosis is a major contributor to the initiation and aggravation of liver injury. Agents that modulate apoptosis may be of therapeutic benefit in a number of liver diseases, and research related to cell type-specific activation or inhibition of apoptotic signaling pathways will provide new strategies for treatment.

Keywords: Liver, hepatitis, alcohol, hepatocarcinoma, cholestasis, fulminant hepatic failure, steatohepatitis, fibrosis

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