Derivatives of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic Acid as Novel Fibrinogen Receptor Antagonists

Title: Derivatives of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic Acid as Novel Fibrinogen Receptor Antagonists

Volume: 5 Issue: 2

Author(s): Olga L. Malovichko, Andrei A. Krysko, Tatyana A. Kabanova, Sergei A. Andronati, Vladimir I. Grishkovets, Vadim V. Kachala and Denis A. Panov

Affiliation:

Keywords: fibrinogen receptor antagonists, αIIbβ3, RGD mimetics, 1,2,3,4-tetrahydroisoquinoline, platelet aggregation

Abstract: It has been proposed a novel method for obtaining of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid as Argmimetic within the framework of search for novel fibrinogen receptor antagonists. New αIIbβ3 antagonists were prepared on a base of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid. Their high antiaggregatory activities in a human platelet rich plasma and ability to block FITC-Fg binding to αIIbβ3 on washed human platelets were estimated.

Cite this article as:

Malovichko L. Olga, Krysko A. Andrei, Kabanova A. Tatyana, Andronati A. Sergei, Grishkovets I. Vladimir, Kachala V. Vadim and Panov A. Denis, Derivatives of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic Acid as Novel Fibrinogen Receptor Antagonists, Medicinal Chemistry 2009; 5 (2) . https://dx.doi.org/10.2174/157340609787582909