Abstract
The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper proposes new approaches for the integration of existing data sources towards a global surveillance network for molecular epidemiology and in silico drug discovery.
Keywords: Avian flu, grid, surveillance network, virtual screening, molecular epidemiology
Infectious Disorders - Drug Targets
Title: Innovative In Silico Approaches to Address Avian Flu Using Grid Technology
Volume: 9 Issue: 3
Author(s): Vincent Breton, Ana Lucia da Costa, Paul de Vlieger, Young-Min Kim, Lydia Maigne, Romain Reuillon, David Sarramia, Nam Hai Truong, Hong Quang Nguyen, Doman Kim and Yin-Ta Wu
Affiliation:
Keywords: Avian flu, grid, surveillance network, virtual screening, molecular epidemiology
Abstract: The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper proposes new approaches for the integration of existing data sources towards a global surveillance network for molecular epidemiology and in silico drug discovery.
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Cite this article as:
Breton Vincent, da Costa Lucia Ana, de Vlieger Paul, Kim Young-Min, Maigne Lydia, Reuillon Romain, Sarramia David, Truong Hai Nam, Nguyen Quang Hong, Kim Doman and Wu Yin-Ta, Innovative In Silico Approaches to Address Avian Flu Using Grid Technology, Infectious Disorders - Drug Targets 2009; 9 (3) . https://dx.doi.org/10.2174/1871526510909030358
DOI https://dx.doi.org/10.2174/1871526510909030358 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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