Solid Phase Synthesis of Oxytocin Analogues Conjugated to Polyamino Polycarboxylic Ligands

Title: Solid Phase Synthesis of Oxytocin Analogues Conjugated to Polyamino Polycarboxylic Ligands

Volume: 6 Issue: 8

Author(s): Luciano Lattuada, Enrico Cappelletti, Mario De Miranda and Chiara Umbelli

Affiliation:

Keywords: Oxytocin, solid phase peptide synthesis, targeting, DOTA, DTPA, radiolabeled peptides

Abstract: An easy solid phase synthesis of oxytocin analogues conjugated to polyaminopolycarboxylic ligand, such as diethylenetriaminepentaacetic acid (DTPA) and tetraazacyclododecanetetraacetic acid (DOTA) is reported. These new products can be labeled with suitable radiometals (e.g. 90Y, 111In, 177Lu), giving rise to radiopharmaceuticals with potential application in imaging and/or therapy of tumors over-expressing oxytocin receptors.

Cite this article as:

Lattuada Luciano, Cappelletti Enrico, De Miranda Mario and Umbelli Chiara, Solid Phase Synthesis of Oxytocin Analogues Conjugated to Polyamino Polycarboxylic Ligands, Letters in Organic Chemistry 2009; 6(8) . https://dx.doi.org/10.2174/157017809790443023