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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Solid Phase Synthesis of Oxytocin Analogues Conjugated to Polyamino Polycarboxylic Ligands

Author(s): Luciano Lattuada, Enrico Cappelletti, Mario De Miranda and Chiara Umbelli

Volume 6, Issue 8, 2009

Page: [624 - 629] Pages: 6

DOI: 10.2174/157017809790443023

Price: $65


An easy solid phase synthesis of oxytocin analogues conjugated to polyaminopolycarboxylic ligand, such as diethylenetriaminepentaacetic acid (DTPA) and tetraazacyclododecanetetraacetic acid (DOTA) is reported. These new products can be labeled with suitable radiometals (e.g. 90Y, 111In, 177Lu), giving rise to radiopharmaceuticals with potential application in imaging and/or therapy of tumors over-expressing oxytocin receptors.

Keywords: Oxytocin, solid phase peptide synthesis, targeting, DOTA, DTPA, radiolabeled peptides

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