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Current Rheumatology Reviews


ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

A Potential Role of Diet in Modulating Peroxisome Proliferator-Activated Receptor (PPAR)-Mediated Signalling in Arthritis

Author(s): Minako Murata and Kayo Masuko

Volume 5, Issue 4, 2009

Page: [246 - 251] Pages: 6

DOI: 10.2174/157339709790192521

Price: $65


Members of the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors are key regulators of glucose and lipid metabolism. Recent studies have demonstrated that PPAR activation plays an important role in inflammatory arthritis. A variety of natural ligands including nutritional elements are known to activate PPARs, suggesting the contribution of dietary nutrients to the regulation of PPAR-mediated gene transcription in the nucleus. This mini-review introduces some aspects of the potential role of these nutrients in modulating the pathophysiology of arthritis through PPAR signalling.

Keywords: PPARs, diet, nutrient, arthritis, review

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