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Current Bioinformatics

Editor-in-Chief

ISSN (Print): 1574-8936
ISSN (Online): 2212-392X

On the Comparison of Classifiers for Microarray Data

Author(s): Blaise Hanczar and Edward R. Dougherty

Volume 5, Issue 1, 2010

Page: [29 - 39] Pages: 11

DOI: 10.2174/157489310790596376

Price: $65

Abstract

The aim of many microarray experiments is to build discriminatory diagnosis and prognosis models. A large number of supervised methods have been proposed in literature for microarray-based classification. Model comparison, which is based on the classification error estimation, is a critical issue. Previous studies have shown that error estimation is unreliable in high-dimensional small-sample settings. This leads naturally to questioning the validity of classificationrule comparison approaches being used in the literature. In this paper we present a brief review of the different comparison methods used in bioinformatics. Then, we test these methods on a set of simulations based on both synthetic and real data. These simulations include different feature-label distributions, classification rules, error estimators and variance estimators. The results show that none of these methods can provide reliable comparison across a wide spectrum of feature-label distributions and classification rules.

Keywords: Microarray classification, error estimation, classifier comparison, variance study


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