Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets


ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Imatinib Mesylate (Gleevec©): Targeted Therapy Against Cancer with Immune Properties

Author(s): Moustapha Zoubir, Thomas Tursz, Cedric Menard, Laurence Zitvogel and Nathalie Chaput

Volume 10, Issue 1, 2010

Page: [1 - 7] Pages: 7

DOI: 10.2174/187153010790827993

Price: $65


The treatment against cancer is being flooded by targeted therapies. Imatinib mesylate (Gleevec©) was the first molecule to provide the proof of principle that targeting an aberrant tyrosine kinase responsible for the uncontrolled cell cycle progression allows for the eradication of tumors. The ideal targeted therapy should eliminate the molecular event responsible for the disease, an oncogenic product such as c-KIT, ABL/BCR and PDGFRα in the case of Gleevec©. Two issues related to this conceptual advance are raised in clinical practice. First, these therapies might target additional pathways generating side effects. Secondly, non tumoral cells bearing the molecular target might respond and induce additional biological outcomes. This review will summarize the by-stander immune modulations promoted by the paradigmatic compound Gleevec©, leading to unexpected new therapeutic indications.

Keywords: Gleevec©, immunity, T cells, NK cells, immunotherapy

Next »

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy