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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Current and Novel Therapies for Hepatitis B Virus Infection

Author(s): K. Sato and M. Mori

Volume 10, Issue 1, 2010

Page: [20 - 31] Pages: 12

DOI: 10.2174/138955710791112613

Price: $65


Many therapeutic reagents for hepatitis B virus infection have established efficacy in goals such as alanine aminotransferase normalization, hepatitis B virus DNA suppression, HBeAg seroconversion, histological improvement, and reduce disease progression. However, it is not established that the efficacy of these reagents for the long-term survival and prevention of hepatocellular carcinoma although recent meta-analyses have also shown antiviral therapy to be efficacious. This article reviews the current status and innovative new options for antiviral therapy for hepatitis B and also discusses the various mechanisms of action for each drug, the results of clinical studies for each therapy, and the problems yet to be solved with respect to hepatitis B treatment.

Keywords: Hepatitis B virus, therapy, host cellular target, life cycle, interferon, nucleoside/nucleotide analog, adverse effects, drug resistance

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