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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Isolation and Characterization of a Novel Small Antifungal Peptide from Bacillus megaterium D4 Isolated from the Dung of Wild Plateau Yak in China

Author(s): Liang Chen and Wuling Chen

Volume 17, Issue 4, 2010

Page: [542 - 546] Pages: 5

DOI: 10.2174/092986610790963627

Price: $65


A novel small antifungal peptide-producing strain D4 was isolated from the dung of wild plateau yak and identified as Bacillus megaterium. The purification procedure of peptide consisted of acid precipitation, methanol extract and C18 reverse-phase chromatography. The amino acid composition of peptide YP differed from those of antifungal peptides which have been reported to date. Peptide YP was proved to be a novel small antifungal cyclic peptide. It exhibited strong inhibitory activity against many phytopathogenic fungi and had a wild range of thermo stability and pH stability and was not susceptible to all proteases tested.

Keywords: Antifungal peptide, Bacillus megaterium, Purification, Thermo stability, Yak dung

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