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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents

Author(s): Guizhi Xiao, Hao Fang, Chengguo Xing and Wenfang Xu

Volume 9, Issue 14, 2009

Page: [1596 - 1604] Pages: 9

DOI: 10.2174/138955709791012238

Price: $65


Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.

Keywords: Apoptosis, Bcl-2, structure, function, inhibitors, anti-tumor

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