Abstract
5-HT2B receptors have been reported to play an important role at cardiac, intestinal and central levels, as well as in bone marrow formation and growth. In the last decade, 5-HT2B receptors have also gained much attention as new targets in therapeutics, but also as off-targets because their activation along with the inhibition of serotonin transporters plays a significant role in the pathogenesis of 5-HT induced valvulopathy. Taking this into account, the present review focuses on the new therapeutic applications of 5-HT2B receptor ligands as well as on the potential concerns.
Current Topics in Medicinal Chemistry
Title: Emerging Opportunities and Concerns for Drug Discovery at Serotonin 5-5-HT2B Receptors
Volume: 10 Issue: 5
Author(s): Jose Brea, Julio Castro-Palomino, Sandra Yeste, Elena Cubero, Antonio Parraga, Eduardo Dominguez and Maria Isabel Loza
Affiliation:
Abstract: 5-HT2B receptors have been reported to play an important role at cardiac, intestinal and central levels, as well as in bone marrow formation and growth. In the last decade, 5-HT2B receptors have also gained much attention as new targets in therapeutics, but also as off-targets because their activation along with the inhibition of serotonin transporters plays a significant role in the pathogenesis of 5-HT induced valvulopathy. Taking this into account, the present review focuses on the new therapeutic applications of 5-HT2B receptor ligands as well as on the potential concerns.
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Cite this article as:
Brea Jose, Castro-Palomino Julio, Yeste Sandra, Cubero Elena, Parraga Antonio, Dominguez Eduardo and Loza Maria Isabel, Emerging Opportunities and Concerns for Drug Discovery at Serotonin 5-5-HT2B Receptors, Current Topics in Medicinal Chemistry 2010; 10 (5) . https://dx.doi.org/10.2174/156802610791111524
DOI https://dx.doi.org/10.2174/156802610791111524 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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