Abstract
There are different types of cyclins, which are active during the cell cycle and enable cyclin-dependent kinases to phosphorylate different substrates. Since there is not much similarity between amino acid sequences of cyclins, predicting these proteins is an important job. This paper presents a bioinformatics classifier to predict cyclins based on Chou's pseudo amino acid composition. Analysis of the results by StAR, which is a program for the analysis of ROC curves, showed that accuracy of the approach was 83.53% (AUC=89.44%). The present work demonstrates that the method can provide useful information for predicting cyclins.
Keywords: Cyclins, Chou’s pseudo amino acid composition, ROC curve analysis
Protein & Peptide Letters
Title: Prediction of Cyclin Proteins Using Chou's Pseudo Amino Acid Composition
Volume: 17 Issue: 10
Author(s): Hassan Mohabatkar
Affiliation:
Keywords: Cyclins, Chou’s pseudo amino acid composition, ROC curve analysis
Abstract: There are different types of cyclins, which are active during the cell cycle and enable cyclin-dependent kinases to phosphorylate different substrates. Since there is not much similarity between amino acid sequences of cyclins, predicting these proteins is an important job. This paper presents a bioinformatics classifier to predict cyclins based on Chou's pseudo amino acid composition. Analysis of the results by StAR, which is a program for the analysis of ROC curves, showed that accuracy of the approach was 83.53% (AUC=89.44%). The present work demonstrates that the method can provide useful information for predicting cyclins.
Export Options
About this article
Cite this article as:
Mohabatkar Hassan, Prediction of Cyclin Proteins Using Chou's Pseudo Amino Acid Composition, Protein & Peptide Letters 2010; 17 (10) . https://dx.doi.org/10.2174/092986610792231564
DOI https://dx.doi.org/10.2174/092986610792231564 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Future Therapeutic Directions: New Medications and Insulin Delivery in a Changing World for Effective Diabetes Management
Current Drug Discovery Technologies Possible Role of Hydroxylated Metabolites of Tacrine in Drug Toxicity and Therapy of Alzheimers Disease
Current Drug Metabolism Comparison with Naloxone of Two Dynorphin a Analogues with K- and δ-Opioid Antagonist Activity
Medicinal Chemistry Protective Coatings for Porcelain Insulators
Recent Patents on Corrosion Science (Discontinued) Pavlovian Sign-Tracking Model of Alcohol Abuse
Current Drug Abuse Reviews Human Immunodeficiency Virus-Mononuclear Phagocyte Interactions:Emerging Avenues of Biomarker Discovery, Modes of Viral Persistence and Disease Pathogenesis
Current HIV Research Anesthesia Issues in Central Nervous System Disorders
Current Aging Science Gadd45 Proteins as Critical Signal Transducers Linking NF-κB to MAPK Cascades
Current Cancer Drug Targets CoMFA and CoMSIA Studies on Aryl Carboxylic Acid Amide Derivatives as Dihydroorotate Dehydrogenase (DHODH) Inhibitors
Current Computer-Aided Drug Design Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
Current Neuropharmacology High Glucose Enhances Neurotoxicity and Inflammatory Cytokine Secretion by Stimulated Human Astrocytes
Current Alzheimer Research Corticotropin Releasing Factor (CRF) Receptor Signaling in the Central Nervous System: New Molecular Targets
CNS & Neurological Disorders - Drug Targets Targeting Extracellular Matrix Proteolysis for Hemorrhagic Complications of tPA Stroke Therapy
CNS & Neurological Disorders - Drug Targets Opioid Substitution Therapy: Achieving Harm Reduction While Searching for a Prophylactic Solution
Current Pharmaceutical Biotechnology Current and Future Applications of Probiotics
Current Nutrition & Food Science In Vivo Transdermal Delivery of Leuprolide Using Microneedles and Iontophoresis
Current Pharmaceutical Biotechnology New Perspective on the Dual Functions of Indirubins in Cancer Therapy and Neuroprotection
Anti-Cancer Agents in Medicinal Chemistry Midazolam Plus Haloperidol as Adjuvant Analgesics to Morphine in Opium Dependent Patients: A Randomized Clinical Trial
Current Drug Abuse Reviews Platelet Alpha- and Beta- Secretase Activities are not Significantly Affected by Dementia or Mild Cognitive Impairment in Swedish Patients
Current Alzheimer Research Reactive Oxygen and Nitrogen Species in Alzheimers Disease
Current Alzheimer Research