An Overview on Synthetic Methodologies and Biological Activities of Pyrazoloquinolines

A.      Gaurav; V.      Gautam; R.      Singh

doi:10.2174/13895575110091194

Abstract

The chemistry of pyrazoloquinolines is well established. This system has proved to be a very attractive scaffold for medicinal chemist in the recent past. Pyrazoloquinolines were extensively studied as bioactive compounds and are known to possess remarkable biological activities such as anti-cancer, anti-anxiety, anti-inflammatory, anti-asthmatic, cerebroprotective and anti-viral among others. For many of the activities the molecular mode of action is known. Recent research efforts have also highlighted the ability of agents based on pyrazoloquinoline skeleton to modulate adenosine A3 receptors and the phosphodiesterase receptors. In this review the developments in the medicinal chemistry of pyrazoloquinolines is discussed.

Keywords: Adenosine receptor, benzodiazepine receptor, Chk1kinase, phosphodiesterase, pyrazoloquinoline, ras, topoisomerase II, SAR, Quinolines, 2-aryl-pyrazolo[4-3-c]quinolin-3-ones, phosphodiesterase IV, PDE IV, benzyloxy)-2-phenylpyrazolo[4,3-c]quinolin-3-one, 9-fluro-2-(2-fluorophenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one, 1-aryl-3-methyl-4,5-dihydro-2H-pyrazolo[4,3-c] quinolin-4-ones, isomeric derivatives, meta substituted 1,3-diaryl[4,5-c]quinolin-4-ones, N-methyl-D-aspartate (NMDA) receptor, 7-chloro-3,5-dihydro-2-(4-methoxyphenyl)-lH-pyrazolo[3,4-c]quinoline-1,4-(2H)-dione, 2-arylpyrazolo[3,4-c]quinoline derivatives, 4-diphenyl-acetylamino-2-phenylpyrazoloquinoline, 4-dibenzoylamino-2-(4-methoxyphenyl)pyrazoloquinoline, unsubstituted 2-phenyl derivatives, anticancer activity, pyrazolo[4,3-c]quinolin-3-one ribonucleosides, Leishmania donovani, 3-amino-9-phenylpyrazolo[3,4-b]quino- lin-4-ones, Plasmodium falciparum, 3-ethoxalylindoles, hydrazine hydrochlorides, anticancer, antiviral, antimalarial, antileish- manial, phosphodiesterase IV antagonist