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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Heterocyclic Compounds as MDR Modulators

Author(s): Gyorgy Hajos, Katalin Jemnitz, Zsuzsanna Riedl, Daniella Takacs and Zsuzsa Veres

Volume 8, Issue 2, 2011

Page: [102 - 113] Pages: 12

DOI: 10.2174/157018011794183815

Price: $65


A survey on MDR modulators containing heterocyclic moiety in the chemical structure for the past 20 years is provided. The discussion of the particular active compound is classified according to the heterocyclic rings involved. The most important biological results are also summarized.

Keywords: MDR modulation, Heterocyclic, Imidazole, Quinoline, Tetrahydroisoquinoline, Phenothiazine, multidrug resistance (MDR), Pglycoprotein (P-gp), protozoan parasite, Nbenzylpiperazine, doxorubicin, 99mTc-tetrofosmin, fluorescence activity, paclitaxel, vincristine, colon carcinoma, cruciferous vegetables, fumitremorgin, mitoxanthrone, tissue polypeptide antigen-A, rhodamine, cyclosporine, tariquidar, anthranylamine, zosuquidar, severe combined immunodeficient (SCID), C6 glioblastoma cell, clomipramine, piperazine, dioxaphosphinane

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