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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Nitric Oxide and the Regulation of Apoptosis in Tumour Cells

Author(s): J. M. Tarr, P. Eggleton and P. G. Winyard

Volume 12, Issue 34, 2006

Page: [4445 - 4468] Pages: 24

DOI: 10.2174/138161206779010477

Price: $65


Nitric oxide (NO) is a small, highly reactive, diffusible free radical which has been implicated in many physiological and pathophysiological processes. It has either pro-apoptotic or anti-apoptotic effects on cells, depending upon a host of factors. This review outlines some of the regulatory molecules and organelles involved in the apoptotic pathways that can be influenced by the presence of NO, including p53, Bcl-2, caspases, mitochondria, and heat shock proteins. The effects of NO on the apoptosis of tumour cells are also examined.

Keywords: Nitric Oxide, Apoptosis, Nitric Oxide Synthase, Tumour Cells

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