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Current Alzheimer Research


ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Recent Advances in Progressive Supranuclear Palsy: A Review

Author(s): L. D. Kaat, W. Z. Chiu, A. J.W. Boon and J. C. van Swieten

Volume 8, Issue 3, 2011

Page: [295 - 302] Pages: 8

DOI: 10.2174/156720511795563809

Price: $65


Progressive Supranuclear Palsy (PSP) has been used to denote a unifying disorder with progressive parkinsonism with early falls, vertical supranuclear gaze palsy, pseudobulbar dysfunction and cognitive decline. Over the last decade, heterogeneity of the disease into different clinical subtypes has been recognized in clinicopathological studies. Although neuroimaging features and laboratory findings may support the diagnosis, true biomarkers are still lacking in the clinical setting. Neuronal and glial tau positive aggregates are predominantly found in basal ganglia and brainstem, and the significant association of PSP with the common H1 tau haplotype likely points to a pathophysiological role of the tau protein in the disease process. Future genetic studies of familial cases and an ongoing genome-wide association study of large series of pathological-proven cases may reveal additional genetic factors in the near future.

Keywords: Progressive supranuclear palsy, review, diagnosis, neuropathology, genetics, Parkinson's disease, MAPT, hallucinations, tremor, dysautonomia, GABAergic cell loss, striatum, cholinergic, dopaminergic cell loss

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