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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Labeling Strategies with F-18 for Positron Emission Tomography Imaging

Author(s): Yonghong Gu, Dong Huang, Zhiguo Liu, Jiaguo Huang and Wenbin Zeng

Volume 7, Issue 5, 2011

Page: [334 - 344] Pages: 11

DOI: 10.2174/157340611796799140

Price: $65


The labeling of probes with fluorine-18 [18F, β(+); 96.7%] continues to play a considerably important role in the development of positron emission tomography (PET) as a modality for both clinical research and clinical diagnoses. This review summarizes the strategies and recent developments in the fluorine-18 labeling of probes for PET imaging. Problems and issues relating to the practical production of fluorine-18 currently in widespread use are also discussed.

Keywords: Probe, fluorination, F-18, positron emission tomography (PET), molecular imaging, labeling chemistry, radiotracer, radiochemists, radiopharmaceuticals, solid-phase, microfluidics, microwave chemistry

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