Abstract
Tumor hypoxia is a negative prognostic factor and its precise imaging is of great relevance to therapy planning. The present review summarizes various strategies of probe design for imaging hypoxia with a variety of techniques such as PET, SPECT and fluorescence imaging. Synthesis of some important probes that are used for preclinical and clinical imaging and their mechanism of binding in hypoxia are also discussed.
Keywords: Hypoxia, Cancer, Molecular Imaging, Radiosynthesis, Fluorination, Fluorine-18, Copper-64, HIF-1, Carbonic Anhydrase IX, Positron Emission Tomography, Fluorescence, Single Photon Emission Computed Tomography
Current Organic Synthesis
Title: Molecular Imaging of Hypoxia: Strategies for Probe Design and Application
Volume: 8 Issue: 4
Author(s): Sandeep Apte, Frederick T. Chin and Edward E. Graves
Affiliation:
Keywords: Hypoxia, Cancer, Molecular Imaging, Radiosynthesis, Fluorination, Fluorine-18, Copper-64, HIF-1, Carbonic Anhydrase IX, Positron Emission Tomography, Fluorescence, Single Photon Emission Computed Tomography
Abstract: Tumor hypoxia is a negative prognostic factor and its precise imaging is of great relevance to therapy planning. The present review summarizes various strategies of probe design for imaging hypoxia with a variety of techniques such as PET, SPECT and fluorescence imaging. Synthesis of some important probes that are used for preclinical and clinical imaging and their mechanism of binding in hypoxia are also discussed.
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Cite this article as:
Apte Sandeep, T. Chin Frederick and E. Graves Edward, Molecular Imaging of Hypoxia: Strategies for Probe Design and Application, Current Organic Synthesis 2011; 8 (4) . https://dx.doi.org/10.2174/157017911796117179
DOI https://dx.doi.org/10.2174/157017911796117179 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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