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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Advances in Semisynthesis, Biosynthesis, Biological Activities,Mode of Action, and Structure-Activity Relationship of Podophyllotoxins:An Update (2008-2010)

Author(s): M. Lv and H. Xu

Volume 11, Issue 10, 2011

Page: [901 - 909] Pages: 9

DOI: 10.2174/138955711796575461

Price: $65


Podophyllotoxin, one of the well-known naturally occurring aryltetralin lignans, has been used as the leadcompound for the preparation of potent anticancer agents, such as etoposide, teniposide, and etopophos. In our previous review, we described the advances of podophyllotoxin derivatives from 2003 and 2007. In recent years, an increased number of interesting research work has been carried out on the podophyllotoxins. As a continuation, the present review summarizes and highlights the update advances of podophyllotoxin derivatives from 2008 and 2010 in regard to semisynthesis, biosynthesis, biological activities, mode of action and structure-biological activity relationship.

Keywords: Podophyllotoxin, anticancer activity, antiviral activity, insecticidal activity, semisynthesis, biosynthesis, mode of action, aryltetralin, teniposide, biological activities

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