Abstract
During the last few decades, numerous stable transgenic mouse strains have been developed in order to mimic a range of Alzheimers disease (AD)-related pathologies. Although none of the models fully replicates the human disease, the models have been a key feature in translational research, providing significant insights into the pathophysiology of AD. They have also been widely used in the preclinical testing of potential therapies. The choice of transgenic mouse model, as well as the stage of Aβ pathology, significantly contributes to the outcome of the studies. Therefore, it is important to combine studies in different transgenic mouse models and detailed in vitro experiments to obtain a complete understanding of the origin of the disease, the actual sequences of early pathological events as well as being able to evaluate the effects of new drugs in the treatment of AD.
Keywords: Amyloid precursor protein, alzheimer's disease, β-amyloid, neurodegeneration, neuropathology, transgenic mice, amyloid cascade hypothesis, hippocampus, hereditary disorder, memory deficits, APP Mutations
Current Alzheimer Research
Title: Transgenic Mice as a Model for Alzheimers Disease
Volume: 8 Issue: 8
Author(s): Christina Unger Lithner, Monika M. Hedberg and Agneta Nordberg
Affiliation:
Keywords: Amyloid precursor protein, alzheimer's disease, β-amyloid, neurodegeneration, neuropathology, transgenic mice, amyloid cascade hypothesis, hippocampus, hereditary disorder, memory deficits, APP Mutations
Abstract: During the last few decades, numerous stable transgenic mouse strains have been developed in order to mimic a range of Alzheimers disease (AD)-related pathologies. Although none of the models fully replicates the human disease, the models have been a key feature in translational research, providing significant insights into the pathophysiology of AD. They have also been widely used in the preclinical testing of potential therapies. The choice of transgenic mouse model, as well as the stage of Aβ pathology, significantly contributes to the outcome of the studies. Therefore, it is important to combine studies in different transgenic mouse models and detailed in vitro experiments to obtain a complete understanding of the origin of the disease, the actual sequences of early pathological events as well as being able to evaluate the effects of new drugs in the treatment of AD.
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Cite this article as:
Unger Lithner Christina, M. Hedberg Monika and Nordberg Agneta, Transgenic Mice as a Model for Alzheimers Disease, Current Alzheimer Research 2011; 8 (8) . https://dx.doi.org/10.2174/156720511798192736
DOI https://dx.doi.org/10.2174/156720511798192736 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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