Abstract
A recent resurgence in the use of compounds to study essential biological processes raises important questions concerning the link between fundamental research and drug development. This article discusses many of the issues involved, in the context of host cell invasion and egress by parasites of the Phylum Apicomplexa. In addition, an overview of the key steps in invasion and egress is provided with a particular emphasis on potential parasite protein drug targets.
Keywords: Apicomplexa, Invasion, Egress, Toxoplasma, Plasmodium, Chemical genetics, Drug discovery, Inhibitors
Current Drug Targets
Title: Targeting Invasion and Egress: From Tools to Drugs?
Volume: 8 Issue: 1
Author(s): R. E. Morgan, K M. Evans, S. Patterson, F. Catti, G. E. Ward and N. J. Westwood
Affiliation:
Keywords: Apicomplexa, Invasion, Egress, Toxoplasma, Plasmodium, Chemical genetics, Drug discovery, Inhibitors
Abstract: A recent resurgence in the use of compounds to study essential biological processes raises important questions concerning the link between fundamental research and drug development. This article discusses many of the issues involved, in the context of host cell invasion and egress by parasites of the Phylum Apicomplexa. In addition, an overview of the key steps in invasion and egress is provided with a particular emphasis on potential parasite protein drug targets.
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Cite this article as:
Morgan E. R., Evans M. K, Patterson S., Catti F., Ward E. G. and Westwood J. N., Targeting Invasion and Egress: From Tools to Drugs?, Current Drug Targets 2007; 8 (1) . https://dx.doi.org/10.2174/138945007779315678
DOI https://dx.doi.org/10.2174/138945007779315678 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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