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Drug Metabolism Letters


ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

ABCB1, SLCO1B1 and UGT1A1 Gene Polymorphisms Are Associated with Toxicity Line Irinotecan

Author(s): Katrin E. Rhodes, Wu Zhang, Dongyun Yang, Oliver A. Press, Michael Gordon, Daniel Vallbohmer, Anne M. Schultheis, Georg Lurje, Robert D. Ladner, William Fazzone, Heinz-Josef Lenz and Syma Iqbal

Volume 1, Issue 1, 2007

Page: [23 - 30] Pages: 8

DOI: 10.2174/187231207779814328


We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.

Keywords: Polymorphisms, colorectal cancer, toxicity, irinotecan

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