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Current HIV Research


ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

SV40 and HIV Sequences in the Cerebrospinal Fluid of a Patient with AIDS Dementia Complex

Author(s): Manola Comar, Pierlanfranco D'Agaro, Roberto Luzzati, Fernanda Martini, Mauro Tognon and Cesare Campello

Volume 5, Issue 3, 2007

Page: [345 - 347] Pages: 3

DOI: 10.2174/157016207780636560

Price: $65


Central Nervous System (CNS) diseases that occur in HIV-positive patients are mainly due to HIV itself or to opportunistic microorganisms. Polyomavirus JCV, BKV and SV40 have been associated with encephalopathies in both HIV-positive and HIV-negative patients. To investigate the presence of Polyomavirus DNA sequences in patients affected by CNS disorders, 82 CSF samples from 70 HIV-positive and 12 HIV-negative patients were analyzed by PCR. A double HIV and SV40 infection was found in one patient suffering with AIDS dementia complex. SV40 DNA sequence analysis showed the homology with wild type SV40 strain. SV40 should be considered as a potential causal agent of CNS disorders in AIDS patients.

Keywords: SV40-HIV co-infection, polyomavirus, AIDS dementia complex

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