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Current Drug Discovery Technologies


ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Targetability of Human Disease Genes

Author(s): Meena K. Sakharkar and Kishore R. Sakharkar

Volume 4, Issue 1, 2007

Page: [48 - 58] Pages: 11

DOI: 10.2174/157016307781115494

Price: $65


The availability of complete genome sequences and the wealth of large-scale biological datasets provide an unprecedented opportunity to elucidate the genetic basis of human diseases. Therapeutically relevant targets should be both ‘druggable’ and ‘disease modifying’. In this review we examine the application of computational biology towards the exploration of druggability, targetability and evolutionary conservation of human disease genes. These analyses could have a tremendous potential for systematic in silico drug target identification in the post-genomic era.

Keywords: Disease genes, drugs, target, model organisms

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