Abstract
Assessment of the risks versus the benefits of hormone replacement therapy has become a challenging task for the physicians. Controversial issues have surrounded the status of hormone replacement therapy for postmenopausal women lately. Several randomized controlled trials present contradicting evidences and have raised questions about the short-term risks of long-term benefits of HRT. Evidence from clinical trials like the WHI and HERS trial does not support HRT use for prevention of cardiovascular disease. The review also discusses the association of hormone replacement therapy and cancer, stroke, cognition, cardiovascular disease, venous thromboembolism, osteoprosis, gall bladdaer disease, and quality of life. The latest controversial results of randomized controlled trials in recent years have posed newer challenges for the physicians in prescribing HRT for postmenopausal women.
Keywords: coronary heart disease (CHD), atherosclerosis, venous thromboembolism, Breast Cancer, estrogen, Gall Bladder Disease
Current Drug Therapy
Title: Current Status of Hormone Replacement Therapy in Post Menopausal Women
Volume: 2 Issue: 1
Author(s): Madhur Gupta and Kamlesh Kohli
Affiliation:
Keywords: coronary heart disease (CHD), atherosclerosis, venous thromboembolism, Breast Cancer, estrogen, Gall Bladder Disease
Abstract: Assessment of the risks versus the benefits of hormone replacement therapy has become a challenging task for the physicians. Controversial issues have surrounded the status of hormone replacement therapy for postmenopausal women lately. Several randomized controlled trials present contradicting evidences and have raised questions about the short-term risks of long-term benefits of HRT. Evidence from clinical trials like the WHI and HERS trial does not support HRT use for prevention of cardiovascular disease. The review also discusses the association of hormone replacement therapy and cancer, stroke, cognition, cardiovascular disease, venous thromboembolism, osteoprosis, gall bladdaer disease, and quality of life. The latest controversial results of randomized controlled trials in recent years have posed newer challenges for the physicians in prescribing HRT for postmenopausal women.
Export Options
About this article
Cite this article as:
Gupta Madhur and Kohli Kamlesh, Current Status of Hormone Replacement Therapy in Post Menopausal Women, Current Drug Therapy 2007; 2 (1) . https://dx.doi.org/10.2174/157488507779422419
DOI https://dx.doi.org/10.2174/157488507779422419 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
Call for Papers in Thematic Issues
Novel Therapeutic Approaches and Biomarkers for Chronic Kidney Disease (CKD)
The thematic issue on "Novel Therapeutic Approaches and Biomarkers for CKD" aims to provide a comprehensive exploration of cutting-edge strategies for the management of chronic kidney disease (CKD). This issue will delve into emerging therapeutic targets, focusing on critical aspects such as podocyte injury, endothelial dysfunction, and tubulointerstitial fibrosis, which ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Genetic and Epigenetic Biomarkers for Diagnosis, Prognosis and Treatment of Metabolic Syndrome
Current Pharmaceutical Design Preface (Hot Topic: Medicinal Strategies in the Treatment of Obesity Guest Editor: Akio Inui)
Current Medicinal Chemistry - Central Nervous System Agents Endothelium and Oxidative Stress: The Pandora's Box of Cerebral (and Non-Only) Small Vessel Disease?
Current Molecular Medicine Atypical Presentation Of Anti-Retroviral Therapy Induced Lactic Acidosis as Acute Right Ventricular Failure And Severe Pulmonary Hypertension
New Emirates Medical Journal Mechanisms and Inhibitors of Apoptosis in Cardiovascular Diseases
Current Pharmaceutical Design Novel Drugs Targeting the c-Ring of the F<sub>1</sub>F<sub>O</sub>-ATP Synthase
Mini-Reviews in Medicinal Chemistry Drug Development and the Importance of Ethnicity: Lessons from Heart Failure Management and Implications for Hypertension
Current Pharmaceutical Design Heart Disease Prediction System using Ensemble of Machine Learning Algorithms
Recent Patents on Engineering Dietary Phytochemicals in Chemoprevention of Cancer: An Update
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Cognitive Function and Heart Failure: The Role of the Adrenergic System
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Blood Pressure and White Matter Lesions in Patients with Vascular Disease: The SMART-MR Study
Current Neurovascular Research Roles of SUMOylation in Heart Development and Cardiovascular Diseases
Current Molecular Medicine The Significance of Endothelium-Derived Hyperpolarizing Factor in the Human Circulation
Current Vascular Pharmacology Autophagy as a Potential Therapeutic Target in Breast Cancer Treatment
Current Cancer Drug Targets Molecular Function of Tocopherols in Age Related Diseases
Current Pharmaceutical Design Investigating the Associations between Mediterranean Diet, Physical Activity and Living Environment with Childhood Asthma using Path Analysis
Endocrine, Metabolic & Immune Disorders - Drug Targets ATP Non-Competitive Ser/Thr Kinase Inhibitors as Potential Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Perceval Sutureless Valve – are Sutureless Valves Here?
Current Cardiology Reviews Hematopoietic Stem Cells Therapies
Current Stem Cell Research & Therapy The Diagnosis of Drug-Induced Liver Disease
Current Clinical Pharmacology